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Regulation of Muscle Differentiation: Stimulation of Myoblast Fusion in vitro by Catecholamines

David H. Curtis and Rosalind J. Zalin
Science
New Series, Vol. 214, No. 4527 (Dec. 18, 1981), pp. 1355-1357
Stable URL: http://www.jstor.org/stable/1687863
Page Count: 3
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Regulation of Muscle Differentiation: Stimulation of Myoblast Fusion in vitro by Catecholamines
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Abstract

Epinephrine and isoproterenol provoke primary chick myoblasts to initiate precocious cell fusion. Both the rise in intracellular adenosine 3′,5′-monophosphate (cyclic AMP) and cell fusion generated by these effectors are prevented by propranolol, which is a specific blocker of the β-adrenergic receptor. Propanolol has no effect either on the precocious cell fusion provoked by prostaglandin E or on cell fusion in control cultures. The results support the idea that a rise in cyclic AMP is the critical intracellular change responsible for initiating events that culminate in myoblast differentiation 4 to 5 hours later. They also indicate that the hormone responsible for the positive regulation of myoblast differentiation in vitro is not acting through the β-adrenergic receptor.

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