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Experimental Hepatic Encephalopathy: Changes in the Binding of γ -aminobutyric Acid

Mario Baraldi and Maria L. Zeneroli
Science
New Series, Vol. 216, No. 4544 (Apr. 23, 1982), pp. 427-429
Stable URL: http://www.jstor.org/stable/1688113
Page Count: 3
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Experimental Hepatic Encephalopathy: Changes in the Binding of γ -aminobutyric Acid
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Abstract

Two populations of receptors for γ-aminobutyric acid, one with low- and the other with high-affinity characteristics, are detectable in frozen, thawed, Tritontreated synaptic membrane preparations from normal brain. It is now reported that membrane preparations from rats with mild galactosamine-induced hepatic encephalopathy show an increase in the number of low- and high-affinity γ-aminobutyric acid binding sites, whereas those from rats with severe encephalopathy show only high-affinity binding sites. Thus, hepatic encephalopathy appears to involve partial degeneration of the γ-aminobutyric acid-containing presynaptic nerve terminals.

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