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Journal Article

Gene Reactivation in Erythrocytes: Nuclear Transplantation in Oocytes and Eggs of Rana

Marie A. DiBerardino and Nancy J. Hoffner
Science
New Series, Vol. 219, No. 4586 (Feb. 18, 1983), pp. 862-864
Stable URL: http://www.jstor.org/stable/1689846
Page Count: 3

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Topics: Erythrocytes, Eggs, Oocytes, Ova, Tadpoles, Larvae, Larval development, Embryos, Adults, Somatic cells
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Gene Reactivation in Erythrocytes: Nuclear Transplantation in Oocytes and Eggs of Rana
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Abstract

Adult erythrocyte nuclei of Rana, transplanted and incubated in the cytoplasm of maturing oocytes, direct matured oocytes to form swimming tadpoles. These results demonstrate that nuclei of noncycling and terminally differentiated erythrocytes contain the genes to specify tadpole development, and conditioning these nuclei in the cytoplasm of oocytes leads to a widespread reactivation of dormant genes.

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