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Separation of Signal Transduction and Adaptation Functions of the Aspartate Receptor in Bacterial Sensing

Andrew F. Russo and Daniel E. Koshland
Science
New Series, Vol. 220, No. 4601 (Jun. 3, 1983), pp. 1016-1020
Stable URL: http://www.jstor.org/stable/1690800
Page Count: 5
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Separation of Signal Transduction and Adaptation Functions of the Aspartate Receptor in Bacterial Sensing
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Abstract

In order to investigate the functions of stimulus recognition, signal transduction, and adaptation, the aspartate receptor gene for bacterial chemotaxis in Salmonella typhimurium has been sequenced and modified. A carboxyl-terminal truncated receptor was shown to bind aspartate and to transmit a signal to change motility behavior. However, the truncated receptor showed greatly reduced methylaccepting capacity, and did not allow adaptation to the sensory stimulation. The separation of receptor functions by alteration of primary structure emphasizes that the receptor is directly involved in adaptation and is not solely a device for transmitting a signal across a membrane.

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