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Expression of Streptococcal M Protein in Escherichia coli

June R. Scott and Vincent A. Fischetti
Science
New Series, Vol. 221, No. 4612 (Aug. 19, 1983), pp. 758-760
Stable URL: http://www.jstor.org/stable/1691032
Page Count: 3
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Expression of Streptococcal M Protein in Escherichia coli
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Abstract

The structural gene for group A streptococcal M protein, the fibrillar surface molecule enabling the organism to resist phagocytosis, has been cloned into Escherichia coli. The molecule produced by Escherichia coli is slightly larger than the M protein isolated by solubilization of the streptococcal cell wall, but is similar in size to that secreted by streptococcal protoplast and L forms. Immunologically, the molecule synthesized by Escherichia coli has the same type-specific determinants as the streptococcal M protein.

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