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How a Nerve Fiber Repairs its Cut End: Involvement of Phospholipase A$_{2}$

Hiromu Yawo and Motoy Kuno
Science
New Series, Vol. 222, No. 4630 (Dec. 23, 1983), pp. 1351-1353
Stable URL: http://www.jstor.org/stable/1691669
Page Count: 3
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How a Nerve Fiber Repairs its Cut End: Involvement of Phospholipase A$_{2}$
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Abstract

Following transection of a giant axon, the nerve membrane at the cut end is resealed within 5 to 30 minutes. This membrane resealing process is highly dependent upon temperature and extracellular calcium ions. The membrane resealing is triggered by excess calcium entering the axoplasm at the site of transection but is prevented by the application of phospholipase A$_{2}$ inhibitors. We propose that calcium activated phospholipase A$_{2}$ plays a central role in resealing of the ruptured nerve membrane.

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