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Imaging Dopamine Receptors in the Human Brain by Positron Tomography

Henry N. Wagner, H. Donald Burns, Robert F. Dannals, Dean F. Wong, Bengt Langstrom, Timothy Duelfer, J. James Frost, Hayden T. Ravert, Jonathan M. Links, Shelley B. Rosenbloom, Scott E. Lukas, Alfred V. Kramer and Michael J. Kuhar
Science
New Series, Vol. 221, No. 4617 (Sep. 23, 1983), pp. 1264-1266
Stable URL: http://www.jstor.org/stable/1691678
Page Count: 3
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Imaging Dopamine Receptors in the Human Brain by Positron Tomography
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Abstract

Neurotransmitter receptors may be involved in a number of neuropsychiatric disease states. The ligand 3-N-[$^{11}$C]methylspiperone, which preferentially binds to dopamine receptors in vivo, was used to image the receptors by positron emission tomography scanning in baboons and in humans. This technique holds promise for noninvasive clinical studies of dopamine receptors in humans.

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