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Long-Lived Oxidants Generated by Human Neutrophils: Characterization and Bioactivity

S. J. Weiss, M. B. Lampert and S. T. Test
Science
New Series, Vol. 222, No. 4624 (Nov. 11, 1983), pp. 625-628
Stable URL: http://www.jstor.org/stable/1691988
Page Count: 4
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Long-Lived Oxidants Generated by Human Neutrophils: Characterization and Bioactivity
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Abstract

Human neutrophils were found to generate an unusual class of oxidants with a half-life of approximately 18 hours and with characteristics similar to, if not identical with, those of N-chloroamines. These neutrophil-derived N-chloroamines have sufficient oxidizing potential to attack sulfhydryl- or thioether-containing compounds and can react with both a methionine-containing chemotactic peptide and a plasma protease inhibitor. As judged by their stability and selective reactivity, the N-chloroamines generated by stimulated neutrophils may play an important role in the local and systemic regulation of inflammatory events in vivo.

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