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Nuclear Localization and DNA Binding Properties of a Protein Expressed by Human c-myc Oncogene

Håkan Persson and Philip Leder
Science
New Series, Vol. 225, No. 4663 (Aug. 17, 1984), pp. 718-721
Stable URL: http://www.jstor.org/stable/1693161
Page Count: 4
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Nuclear Localization and DNA Binding Properties of a Protein Expressed by Human c-myc Oncogene
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Abstract

Antisera to the human cellular myc oncogene product were used to identify a human c-myc specific protein with a molecular weight of 65,000. Subcellular fractionation showed that the human c-myc protein is predominantly found in the cell nucleus. The p65 K$^{c\text{-}myc}$ protein binds to double- and single-stranded DNA as measured by a DNA affinity chromatography assay.

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