Access

You are not currently logged in.

Access your personal account or get JSTOR access through your library or other institution:

login

Log in to your personal account or through your institution.

Homologies between Signal Transducing G Proteins and ras Gene Products

James B. Hurley, Melvin I. Simon, David B. Teplow, Janet D. Robishaw and Alfred G. Gilman
Science
New Series, Vol. 226, No. 4676 (Nov. 16, 1984), pp. 860-862
Stable URL: http://www.jstor.org/stable/1693286
Page Count: 3
  • More info
  • Cite this Item
Homologies between Signal Transducing G Proteins and ras Gene Products
Preview not available

Abstract

The guanosine triphosphate-binding proteins (G proteins) found in a variety of tissues transduce signals generated by ligand binding to cell surface receptors into changes in intracellular metabolism. Amino acid sequences of peptides prepared by partial proteolysis of the α subunit of a bovine brain G protein and the α subunit of rod outer-segment transducin were determined. The two proteins show regions of sequence identity as well as regions of diversity. A portion of the amino-terminal peptide sequence of each protein is highly homologous with the corresponding region in the ras protein (a protooncogene product). These similarities suggest that G proteins and ras proteins may have analogous functions.

Page Thumbnails

  • Thumbnail: Page 
860
    860
  • Thumbnail: Page 
861
    861
  • Thumbnail: Page 
862
    862