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Separation of Morphine Analgesia from Physical Dependence

Geoffrey S. F. Ling, Janet M. MacLeod, Shay Lee, Stephen H. Lockhart and Gavril W. Pasternak
Science
New Series, Vol. 226, No. 4673 (Oct. 26, 1984), pp. 462-464
Stable URL: http://www.jstor.org/stable/1694093
Page Count: 3
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Separation of Morphine Analgesia from Physical Dependence
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Abstract

Intravenous infusion of morphine sulfate in rats for 24 hours produced marked opioid dependence, manifested by a series of well-documented signs appearing after injection of the opiate antagonist naloxone. Treatment of rats with naloxonazine significantly reduced the analgesia associated with the morphine infusions for more than 24 hours. Furthermore, 14 of 16 withdrawal signs observed in naloxonazine-treated rats were virtually identical to those in rats that received morphine alone. These results raise the possibility that different receptor mechanisms mediate morphine analgesia and many of the withdrawal signs associated with morphine dependence.

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