Access

You are not currently logged in.

Access your personal account or get JSTOR access through your library or other institution:

login

Log in to your personal account or through your institution.

Developmentally Controlled Expression of Immunoglobulin V$_{\text{H}}$ Genes

Roger M. Perlmutter, John F. Kearney, Sandra P. Chang and Leroy E. Hood
Science
New Series, Vol. 227, No. 4694 (Mar. 29, 1985), pp. 1597-1601
Stable URL: http://www.jstor.org/stable/1694902
Page Count: 5
  • More info
  • Cite this Item
Developmentally Controlled Expression of Immunoglobulin V$_{\text{H}}$ Genes
Preview not available

Abstract

Although antibody diversity arises mainly from apparently random combinatorial and somatic mutational mechanisms acting upon a limited number of germline antibody genes, the antibody repertoire develops in an ordered fashion during mammalian ontogeny. A series of early pre-B and B-lymphocyte cell lines were examined to determine whether an ordered rearrangement of gene families of the variable region of immunoglobulin heavy chains (V$_{H}$) may be the basis for the programmed development of the antibody response. The results indicated that the V$_{H}$ repertoire of fetal B-lineage cells is largely restricted to the V$_{H}$ 7183 gene family and that subsequent recruitment of additional V$_{H}$ gene families occurs during neonatal development. These results have important implications in understanding the ontogeny of immune function.

Page Thumbnails

  • Thumbnail: Page 
1597
    1597
  • Thumbnail: Page 
1598
    1598
  • Thumbnail: Page 
1599
    1599
  • Thumbnail: Page 
1600
    1600
  • Thumbnail: Page 
1601
    1601