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Sequence Homology between Certain Viral Proteins and Proteins Related to Encephalomyelitis and Neuritis

Ulrike Jahnke, Edmond H. Fischer and Ellsworth C. Alvord
Science
New Series, Vol. 229, No. 4710 (Jul. 19, 1985), pp. 282-284
Stable URL: http://www.jstor.org/stable/1695179
Page Count: 3
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Sequence Homology between Certain Viral Proteins and Proteins Related to Encephalomyelitis and Neuritis
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Abstract

Post-infectious or post-vaccinal demyelinating encephalomyelitis and neuritis may be due to immunological cross-reactions evoked by specific viral antigenic determinants (epitopes) that are homologous to regions in the target myelins of the central and peripheral nervous systems. Such homologies have been found by computer searches in which decapeptides in two human myelin proteins were compared with proteins of viruses known to infect humans. These viruses include measles, Epstein-Barr, influenza A and B, and others that cause upper respiratory infections. Several regions identified in myelin basic protein and P$_{2}$ protein can be related to experimental allergic encephalomyelitis or neuritis in laboratory animals

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