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Corticotropin-Releasing Activity of Monokines

B. M. R. N. J. Woloski, E. M. Smith, W. J. Meyer, G. M. Fuller and J. E. Blalock
Science
New Series, Vol. 230, No. 4729 (Nov. 29, 1985), pp. 1035-1037
Stable URL: http://www.jstor.org/stable/1695325
Page Count: 3
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Corticotropin-Releasing Activity of Monokines
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Abstract

Hepatocyte-stimulating factor and interleukin-1 are proteins produced by monocytes in response to inflammatory challenge. Neither of these monokines had direct effects on steroid production by cultured adrenocortical cells. Both monokines stimulated pituitary cells (AtT-20) to release adrenocorticotropic hormone; interleukin-1 was equipotent with a combination of corticotropin-releasing factor and arginine vasopressin, and hepatocyte-stimulating factor was at least three times as effective. The synthetic glucocorticoid, dexamethasone, inhibited production of hepatocyte-stimulating factor by cultured monocytes. These results indicate an axis between monocytes and pituitary and adrenocortical cells which may play a role in regulating host defense.

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