You are not currently logged in.
Access your personal account or get JSTOR access through your library or other institution:
Corticotropin-Releasing Activity of Monokines
B. M. R. N. J. Woloski, E. M. Smith, W. J. Meyer, G. M. Fuller and J. E. Blalock
New Series, Vol. 230, No. 4729 (Nov. 29, 1985), pp. 1035-1037
Published by: American Association for the Advancement of Science
Stable URL: http://www.jstor.org/stable/1695325
Page Count: 3
Preview not available
Hepatocyte-stimulating factor and interleukin-1 are proteins produced by monocytes in response to inflammatory challenge. Neither of these monokines had direct effects on steroid production by cultured adrenocortical cells. Both monokines stimulated pituitary cells (AtT-20) to release adrenocorticotropic hormone; interleukin-1 was equipotent with a combination of corticotropin-releasing factor and arginine vasopressin, and hepatocyte-stimulating factor was at least three times as effective. The synthetic glucocorticoid, dexamethasone, inhibited production of hepatocyte-stimulating factor by cultured monocytes. These results indicate an axis between monocytes and pituitary and adrenocortical cells which may play a role in regulating host defense.
Science © 1985 American Association for the Advancement of Science