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Enhanced Metabolism of Leishmania donovani Amastigotes at Acid pH: An Adaptation for Intracellular Growth
Antony J. Mukkada, John C. Meade, Theresa A. Glaser and Peter F. Bonventre
New Series, Vol. 229, No. 4718 (Sep. 13, 1985), pp. 1099-1101
Published by: American Association for the Advancement of Science
Stable URL: http://www.jstor.org/stable/1695820
Page Count: 3
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Amastigotes (tissue forms) of Leishmania donovani isolated from infected hamster spleens carried out several physiological activities (respiration, catabolism of energy substrates, and incorporation of precursors into macromolecules) optimally at pH 4.0 to 5.5. All metabolic activities that were examined decreased sharply above the optimal pH. Promastigotes (culture forms), on the other hand, carried out the same metabolic activities optimally at or near neutral pH. This adaptation to an acid environment may account in part for the unusual ability of amastigotes to survive and multiply within the acidic environment of the phagolysosomes in vivo.
Science © 1985 American Association for the Advancement of Science