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A Blood Vessel Model Constructed from Collagen and Cultured Vascular Cells
Crispin B. Weinberg and Eugene Bell
New Series, Vol. 231, No. 4736 (Jan. 24, 1986), pp. 397-400
Published by: American Association for the Advancement of Science
Stable URL: http://www.jstor.org/stable/1696609
Page Count: 4
You can always find the topics here!Topics: Collagens, Endothelial cells, Blood vessels, Smooth muscle myocytes, Arteries, Cultured cells, Lumens, Cells, Endothelium, Mandrels
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A model of a blood vessel was constructed in vitro. Its multilayered structure resembled that of an artery and it withstood physiological pressures. Electron microscopy showed that the endothelial cells lining the lumen and the smooth muscle cells in the wall were healthy and well differentiated. The lining of endothelial cells functioned physically, as a permeability barrier, and biosynthetically, producing von Willebrand's factor and prostacyclin. The strength of the model depended on its multiple layers of collagen integrated with a Dacron mesh.
Science © 1986 American Association for the Advancement of Science