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Accelerated Healing of Incisional Wounds in Rats Induced by Transforming Growth Factor-$\beta $

Thomas A. Mustoe, Glenn F. Pierce, Arlen Thomason, Peggy Gramates, Michael B. Sporn and Thomas F. Deuel
Science
New Series, Vol. 237, No. 4820 (Sep. 11, 1987), pp. 1333-1336
Stable URL: http://www.jstor.org/stable/1700007
Page Count: 4
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Accelerated Healing of Incisional Wounds in Rats Induced by Transforming Growth Factor-$\beta $
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Abstract

The role of polypeptide growth factors in the processes of inflammation and repair was investigated by analyzing the influence of transforming growth Factor-$\beta $ (TGF-$\beta $), applied directly to linear incisions made through rat dorsal skin. A dose-dependent, direct stimulatory effect of a single application of TGF-$\beta $ on the breaking strength of healing incisional wounds was demonstrated. An increase in maximum wound strength of 220 percent of control was observed at 5 days; the healing rate was accelerated by approximately 3 days for at least 14 days after production of the wound and application of TGF-$\beta $ These increases in wound strength were accompanied by an increased influx of mononuclear cells and fibroblasts and by marked increases in collagen deposition at the site of application of TGF-$\beta $. TGF-$\beta $ is thus a potent pharmacologic agent that can accelerate wound healing in rats.

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