Access

You are not currently logged in.

Access your personal account or get JSTOR access through your library or other institution:

login

Log in to your personal account or through your institution.

Molecular Genetics: Applications to the Clinical Neurosciences

Joseph B. Martin
Science
New Series, Vol. 238, No. 4828 (Nov. 6, 1987), pp. 765-772
Stable URL: http://www.jstor.org/stable/1700353
Page Count: 8
  • More info
  • Cite this Item
Molecular Genetics: Applications to the Clinical Neurosciences
Preview not available

Abstract

Application of molecular biology, by means of linkage analysis and DNA probes that demonstrate restriction fragment length polymorphisms (RFLPs), has resulted in the chromosomal localization of the genes responsible for a number of neurological disorders. Characterization of the structure and function of individual genes for these diseases is in an early stage, but information available indicates that the molecular mechanisms underlying phenotypic expression of neurological diseases encompass a wide range of genetic errors ranging from the most minor (a single-base pair mutation) to large chromosomal deletions. Linkage analysis can now be used for genetic counseling in several of these disorders.

Page Thumbnails

  • Thumbnail: Page 
765
    765
  • Thumbnail: Page 
766
    766
  • Thumbnail: Page 
767
    767
  • Thumbnail: Page 
768
    768
  • Thumbnail: Page 
769
    769
  • Thumbnail: Page 
770
    770
  • Thumbnail: Page 
771
    771
  • Thumbnail: Page 
772
    772