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Signal for Attachment of a Phospholipid Membrane Anchor in Decay Accelerating Factor

Ingrid W. Caras, Gregory N. Weddell, Michael A. Davitz, Victor Nussenzweig and David W. Martin
Science
New Series, Vol. 238, No. 4831 (Nov. 27, 1987), pp. 1280-1283
Stable URL: http://www.jstor.org/stable/1700810
Page Count: 4
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Signal for Attachment of a Phospholipid Membrane Anchor in Decay Accelerating Factor
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Abstract

Decay accelerating factor (DAF) belongs to a novel group of membrane proteins anchored to the cell surface by a glycophospholipid membrane anchor that is covalently attached to the carboxyl terminus of the protein. The last 37 amino acids of membrane DAF, when fused to the carboxyl terminus of a secreted protein, are sufficient to target the fusion protein to the plasma membrane by means of a glycophospholipid anchor. This approach provides a novel means of targeting proteins to the cell-surface membrane.

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