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Developmental Regulation of Two 5S Ribosomal RNA Genes

Alan P. Wolffe and Donald D. Brown
Science
New Series, Vol. 241, No. 4873 (Sep. 23, 1988), pp. 1626-1632
Stable URL: http://www.jstor.org/stable/1702230
Page Count: 7
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Developmental Regulation of Two 5S Ribosomal RNA Genes
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Abstract

The developmental regulation of two kinds of Xenopus 5S RNA genes (oocyte and somatic types) can be explained by differences in the stability of protein-protein and protein-DNA interactions in a transcription complex that directs transcription initiation by RNA polymerase III. Dissociation of transcription factors from oocyte 5S RNA genes during development allows them to be repressed by chromatin assembly. In the same cells, somatic 5S RNA genes remain active because their transcription complexes are stable.

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