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Astrocytes Synthesize Angiotensinogen in Brain

Ruth L. Stornetta, Charlyn L. Hawelu-Johnson, Patrice G. Guyenet and Kevin R. Lynch
Science
New Series, Vol. 242, No. 4884 (Dec. 9, 1988), pp. 1444-1446
Stable URL: http://www.jstor.org/stable/1702336
Page Count: 3
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Astrocytes Synthesize Angiotensinogen in Brain
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Abstract

Cell types associated with angiotensinogen mRNA in rat brain were identified in individual brain sections by in situ hybridization with tritiated RNA probes or with a sulfur-35-labeled oligonucleotide combined with immunocytochemical detection of either glial fibrillary acidic protein (GFAP) for astrocytes or microtubule-associated protein (MAP-2) for neurons. Autoradiography revealed silver grains clustered primarily over GFAP-reactive soma and processes; most grain clusters were not associated with MAP-2-reactive cells. These results demonstrate that, in contrast to other known neuropeptide precursors, angiotensinogen is synthesized by glia.

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