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Journal Article

Hybridization of Half Molecules of Rabbit Gamma Globulin

A. Nisonoff and J. L. Palmer
Science
New Series, Vol. 143, No. 3604 (Jan. 24, 1964), pp. 376-379
Stable URL: http://www.jstor.org/stable/1711798
Page Count: 4

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Topics: Molecules, Adsorption, Milk, Radioactive decay, pH, Sodium, Precipitates, Antibodies, Chlorides, Antigens
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Hybridization of Half Molecules of Rabbit Gamma Globulin
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Abstract

Specifically purified rabbit antiovalbumin and normal γ -globulin labeled with 1-131 were dissociated into half molecules by reduction and acidification. When a mixture of the two preparations was neutralized, a large proportion of mixed molecules having active combining sites and the same sedimentation coefficient as the original γ -globulins was formed. Since the sulfhydryl groups were inactivated after reduction, the recombined subunits appear to be linked by noncovalent bonds.

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