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Actinomycin D Effects in Frog Embryos: Evidence for Sequential Synthesis of DNA-Dependent RNA

Reed A. Flickinger
Science
New Series, Vol. 141, No. 3585 (Sep. 13, 1963), pp. 1063-1064
Stable URL: http://www.jstor.org/stable/1712367
Page Count: 2
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Abstract

Early gastrulae of Rana pipiens exposed to actinomycin D for 2 days were then cultured in saline. The resulting larvae were immotile; histological examination revealed impaired development of axial nerve and muscle tissues, but normal differentiation of sensory, pronephric, heart, and digestive tissues; this suggests sequential synthesis of the different tissue-specific molecules of DNA-dependent RNA.

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