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Journal Article

Insect Chemosterilants with Low Toxicity for Mammals

Shen Chin Chang, Paul H. Terry and Alexej B. Bořkovec
New Series, Vol. 144, No. 3614 (Apr. 3, 1964), pp. 57-58
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Topics: Flies, Stomach, Blood, Toxicity, Nerves, Neck, Jugular vein, Eggs, Sterilizing, Dosage
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Hexamethylphosphoramide and hexamethylmelamine are effective as male house fly chemosterilants. Both compounds are structurally similar to the two highly active sterilants tepa and tretamine, but they differ from the aziridinyl compounds in their low toxicity for mammals and in their lack of alkylating properties. This discovery of nonalkylating male sterilants of low toxicity should substantially increase the scope and practicality of the sterilemale control method.

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