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Glycoprotein Biosynthesis in Human Reticulocytes: A Lesion in Thalassemia

Edwin H. Eylar and Gastone T. Matioli
Science
New Series, Vol. 147, No. 3660 (Feb. 19, 1965), pp. 869-870
Stable URL: http://www.jstor.org/stable/1715489
Page Count: 2
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Abstract

The rate of incorporation of glucosamine into the glycoprotein of reticulocyte stroma is greatly increased in thalassemia. This increase suggests a major enzymic disorder in the buildup of cellular membrane and reconciles the accumulation of material showing a positive reaction with periodic acid Schiff reagent with the clinical picture of oligocythemia and microcytosis.

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