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Adrenaline Synthesis: Control by the Pituitary Gland and Adrenal Glucocorticoids

Richard J. Wurtman and Julius Axelrod
Science
New Series, Vol. 150, No. 3702 (Dec. 10, 1965), pp. 1464-1465
Stable URL: http://www.jstor.org/stable/1717009
Page Count: 2
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Abstract

The activity of phenylethanolamine-N-methyl transferase, an enzyme that synthesizes adrenaline from noradrenaline in the adrenal medulla, is markedly depressed following hypophysectomy. Enzyme activity is restored to normal after administration of ACTH or the potent glucocorticoid, dexamethasone. Thus the biosynthesis of adrenaline in the adrenal medulla appears to be regulated by the pituitary-adrenocortical system.

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