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Immunoglobulin A Production in Ataxia Telangiectasia

D. E. McFarlin, W. Strober, R. D. Wochner and T. A. Waldmann
Science
New Series, Vol. 150, No. 3700 (Nov. 26, 1965), pp. 1175-1177
Stable URL: http://www.jstor.org/stable/1717770
Page Count: 3
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Immunoglobulin A Production in Ataxia Telangiectasia
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Abstract

Serum from five patients with ataxia telangiectasia contained no detectable immunoglobulin A (IgA). However, there was evidence (by immunofluorescence) of IgA in the bone marrow of the three patients so examined, suggesting that the defect in IgA production was not complete. IgA was in the saliva of all five patients and in the parotid gland of the one patient studied. This is further evidence of IgA synthesis by the salivary glands.

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