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Immunoglobulin A Production in Ataxia Telangiectasia
D. E. McFarlin, W. Strober, R. D. Wochner and T. A. Waldmann
New Series, Vol. 150, No. 3700 (Nov. 26, 1965), pp. 1175-1177
Published by: American Association for the Advancement of Science
Stable URL: http://www.jstor.org/stable/1717770
Page Count: 3
You can always find the topics here!Topics: Saliva, Antiserum, Immunoglobulins, Bone marrow, Plasma cells, Ataxia telangiectasia, Fluorescence, Acinar cells, Globulins, Cell nucleus
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Serum from five patients with ataxia telangiectasia contained no detectable immunoglobulin A (IgA). However, there was evidence (by immunofluorescence) of IgA in the bone marrow of the three patients so examined, suggesting that the defect in IgA production was not complete. IgA was in the saliva of all five patients and in the parotid gland of the one patient studied. This is further evidence of IgA synthesis by the salivary glands.
Science © 1965 American Association for the Advancement of Science