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Actinomycin D: Inhibition of Respiration and Glycolysis

John Laszlo, Donald S. Miller, Kenneth S. McCarty and Paul Hochstein
Science
New Series, Vol. 151, No. 3713 (Feb. 25, 1966), pp. 1007-1010
Stable URL: http://www.jstor.org/stable/1718698
Page Count: 4
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Actinomycin D: Inhibition of Respiration and Glycolysis
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Abstract

Actinomycin D inhibited respiration and anaerobic glycolysis of human leukemic leukocytes and lowered the adenosine triphosphate content of the cells. Inhibitory effects on respiration and on RNA synthesis could not be dissociated from one another over a wide range of drug concentrations. Actinomycin D also impaired protein synthesis, probably by decreasing the availability of adenosine triphosphate and by inhibiting messenger RNA.

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