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Amino Acid Transport: Evidence for Genetic Control of Two Types in Human Kidney

C. R. Scriver and O. H. Wilson
Science
New Series, Vol. 155, No. 3768 (Mar. 17, 1967), pp. 1428-1430
Stable URL: http://www.jstor.org/stable/1721199
Page Count: 3
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Amino Acid Transport: Evidence for Genetic Control of Two Types in Human Kidney
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Abstract

A mutation affecting renal transport of proline, hydroxyproline, and glycerine occurs in man. In the presumed homozygote there is still significant residual transport of these compounds; however, this remaining function is saturated at normal concentrations of substrate in the plasma and is not inhibited by L-proline in the expected way. The presumed heterozygote has partial loss of a transport system common to the three substrates, which becomes saturated at high concentrations of substrate and is inhibited by L-proline. Two different types of transport systems are proposed: a common system and systems with lower capacity and greater specificity. The two types of transport appear to be controlled by separate genes.

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