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Conversion of Beta Sitosterol to Cholesterol Blocked in an Insect by Hypocholesterolemic Agents

J. A. Svoboda and W. E. Robbins
Science
New Series, Vol. 156, No. 3782 (Jun. 23, 1967), pp. 1637-1638
Stable URL: http://www.jstor.org/stable/1721612
Page Count: 2
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Abstract

Two vertebrate hypocholesterolemic agents (triparanol and 22,25-diazacholesterol) block the conversion of β-sitosterol to cholesterol in the larva of the tobacco hornworm, Manduca sexta (Johannson). A primary site of inhibitory action is the terminal step in this conversion-the reduction of desmosterol (24-dehydrocholesterol) to cholesterol. This is also the site at which these compounds inhibit de novo cholesterol biosynthesis in higher animals. Both agents severely inhibit growth and maturation of the tobacco hornworm.

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