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Leukotactic Factor Elaborated by Mixtures of Genetically Dissimilar Cells
New Series, Vol. 157, No. 3788 (Aug. 4, 1967), pp. 554-556
Published by: American Association for the Advancement of Science
Stable URL: http://www.jstor.org/stable/1721707
Page Count: 3
You can always find the topics here!Topics: Lymphocytes, Cellular immunity, Transplantation immunology, Cultured cells, Skin, Homologous transplantation, Animals, Cell culture techniques, Inbred strains, Lymph nodes
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Mixtures of immunologically competent cells, from genetically dissimilar donors from inbred strains of mice, rats, or Syrian hamsters, cultivated in vitro elaborate into the medium a factor capable of attracting polymorphonuclear cells when it is injected into the skin of irradiated hamsters. Supernatant medium of cultured node cells from genetically identical donors contains no leukotactic activity. The degree of the cell accumulation seemed to parallel closely the degree of histoincompatibility.
Science © 1967 American Association for the Advancement of Science