Access

You are not currently logged in.

Access your personal account or get JSTOR access through your library or other institution:

login

Log in to your personal account or through your institution.

Myoglobin Subfractions: Abnormality in Duchenne Type of Progressive Muscular Dystrophy

Kazuo Miyoshi, Kazuo Saijo, Yojiro Kuryu, Yasuo Oshima, Masuhiro Nakano and Hisaomi Kawai
Science
New Series, Vol. 159, No. 3816 (Feb. 16, 1968), pp. 736-737
Stable URL: http://www.jstor.org/stable/1723189
Page Count: 2
  • More info
  • Cite this Item
Preview not available
Preview not available

Abstract

Human metmyoglobin was separated electrophoretically into four subfractions: Mb$_{1}$, Mb$_{2}$, Mb$_{3}$ and Mb$_{4}$, which divide into at least two biochemically independent groups: Mb$_{1}$ and Mb$_{2}$, and Mb$_{3}$ and Mb$_{4}$. In normal subjects, Mb$_{1}$ constituted the predominant component, Mb$_{2}$, Mb$_{3}$, and Mb$_{4}$ were the minor components in this descending order. In the Duchenne type of progressive muscular dystrophy, on the contrary, a remarkable decrease in Mb$_{1}$ and a concomitant increase in Mb$_{3}$ were observed. This unique abnormality in the relative distribution of myoglobin subfractions was recognized only in the Duchenne type and not in other types of progressive muscular dystrophy or in other myopathies.

Page Thumbnails

  • Thumbnail: Page 
736
    736
  • Thumbnail: Page 
737
    737