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Journal Article

Concanavalin A in vivo: Induction of Hemorrhagic Skin Lesions (Arthus-Like Reactions) in Mice

Leon S. Kind and Warren A. Petersen
Science
New Series, Vol. 160, No. 3825 (Apr. 19, 1968), pp. 312-313
Stable URL: http://www.jstor.org/stable/1723773
Page Count: 2

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Topics: Lesions, Precipitates, Animals, Skin, Mice, Lectins, Lymphocytes, Polysaccharides, Biochemistry, Glycoproteins
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Abstract

Concanavalin A injected into the skin of mice induced the formation of hemorrhagic Arthus-like lesions. No lesions resulted if concanavalin A was adsorbed with insoluble $\alpha _{2}$-macroglobulin or if mice were first treated with nitrogen mustard. The ability of concanavalin A, phytohemag-glutinin, or pokeweed mitogen to induce skin lesions seemed to parallel their ability to precipitate serum proteins.

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