Access

You are not currently logged in.

Access your personal account or get JSTOR access through your library or other institution:

login

Log in to your personal account or through your institution.

Thymine-Thymine Adduct as a Photoproduct of Thymine

A. J. Varghese and S. Y. Wang
Science
New Series, Vol. 160, No. 3824 (Apr. 12, 1968), pp. 186-187
Stable URL: http://www.jstor.org/stable/1724082
Page Count: 2
  • More info
  • Cite this Item
Preview not available
Preview not available

Abstract

A product isolated from thymine irradiated with ultraviolet light in frozen aqueous solution undergoes dehydration on heating with acids. As judged by elemental analysis, mass, ultraviolet, infrared, and nuclear magnetic resonance spectra, the most probable structures for this compound and its dehydration product, respectively, are 5-hydroxy-6-4′-[5$^{′-methylpyrimidin-2′-one]-dihydrothymine and 6-4′-[5′-methylpyrimidin-2′-one]-thymine. Apparently, this compound is a thymine-thymine adduct and presumably is formed through the rearrangement of an initial photoproduct. Both compounds are closely related to 6-4′-[pyrimidin-2′-one]-thymine which has been isolated from acid hydrolyzates of ultraviolet-irradiated DNA and supposedly is derived from cytosine-thymine adduct. Formation of such adducts between pyrimidine bases is apparently a common photoreaction and may be important to the study of the photochemistry and photobiology of nucleic acids.

Page Thumbnails

  • Thumbnail: Page 
186
    186
  • Thumbnail: Page 
187
    187