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Mutant Sl Alleles of Mice Affect Susceptibility to Friend Spleen Focus-Forming Virus

M. Bennett, R. A. Steeves, G. Cudkowicz, E. A. Mirand and L. B. Russell
Science
New Series, Vol. 162, No. 3853 (Nov. 1, 1968), pp. 564-565
Stable URL: http://www.jstor.org/stable/1724927
Page Count: 2
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Abstract

Mice of genotypes Sl/Sl$^{\text{d}}$, Sl/+, and Sl$^{\text{d}}$/+ (but not Sl$^{\text{T}}$/Sl$^{\text{T}}$ or Sl$^{\text{T}}$/+) were resistant to spleen focus-forming virus. The "environment" in which hemopoietic target cells for this virus develop was not conducive for infection or focus formation, or both, but the target cells were not altered directly. The same genes appear to regulate hemopoiesis and leukemogenic transformation.

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