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Activation of Hageman Factor by L-Homocystine

Oscar D. Ratnoff
Science
New Series, Vol. 162, No. 3857 (Nov. 29, 1968), pp. 1007-1009
Stable URL: http://www.jstor.org/stable/1725251
Page Count: 3
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Activation of Hageman Factor by L-Homocystine
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Abstract

L-Homocystine activates Hageman factor, as demonstrated by its capacity to initiate clotting and to induce the evolution of plasma kinins. Perhaps, strategically located deposits of this amino acid are responsible for the unusual frequency of thrombosis in patients with homocystinuria.

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