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25-Hydroxycholecalciferol: Direct Effect on Calcium Transport

E. B. Olson and H. F. DeLuca
Science
New Series, Vol. 165, No. 3891 (Jul. 25, 1969), pp. 405-407
Stable URL: http://www.jstor.org/stable/1727577
Page Count: 3
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25-Hydroxycholecalciferol: Direct Effect on Calcium Transport
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Abstract

The perfused small intestine from a vitamin D deficient rat exhibits about one-half the calcium transport of the intestine from a rat given vitamin D. These levels of calcium transport can be maintained for at least 4 hours. Addition of 2.5 micrograms of 25-hydroxycholecalciferol added to the vitamin D deficient intestine via the arterial blood perfusate induces a rise in calcium transport to +D levels within 2 hours. In contrast, 250 micrograms of vitamin D$_{3}$ given in the same manner has no effect on the calcium transport level over a 4-hour period. These data provide strong evidence that 25-hydroxycholecalciferol represents the metabolically active form of vitamin D$_{3}$.

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