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Colcemid Sensitivity of Fission Yeast and the Isolation of Colcemid-Resistant Mutants

Seymour Lederberg and Gail Stetten
Science
New Series, Vol. 168, No. 3930 (Apr. 24, 1970), pp. 485-487
Stable URL: http://www.jstor.org/stable/1729244
Page Count: 3
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Colcemid Sensitivity of Fission Yeast and the Isolation of Colcemid-Resistant Mutants
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Abstract

Cell division of the fission yeast, Schizosaccharomyces pombe, is reversibly inhibited by the antimitotic agent Colcemid (N-deacetyl-N-methylcolchicine) in nutrient medium. Cell growth continues until all cells become nonseparating cell doublets in a V configuration. Mutants have been isolated capable of uninhibited growth in the presence of concentrations of Colcemid mycostatic for the parent strain.

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