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DNA Synthesis in Differentiating Skeletal Muscle Cells: Initiation by Ultraviolet Light
Frank E. Stockdale
New Series, Vol. 171, No. 3976 (Mar. 19, 1971), pp. 1145-1147
Published by: American Association for the Advancement of Science
Stable URL: http://www.jstor.org/stable/1730605
Page Count: 3
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As skeletal muscle cells differentiate, they fail to initiate DNA synthesis. This rigid regulation, which persists even after cells are fully developed, does not extend to "repair" DNA synthesis, in that ultraviolet light initiates DNA synthesis in 99 percent of the muscle nuclei exposed. The rate of "repair" DNA synthesis in these nuclei, however, drops over 50 percent at the time of cell differentiation.
Science © 1971 American Association for the Advancement of Science