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Adenosine 3′,5′-Monophosphate in Nervous Tissue: Increase Associated with Synaptic Transmission

Donald A. McAfee, Michel Schorderet and Paul Greengard
Science
New Series, Vol. 171, No. 3976 (Mar. 19, 1971), pp. 1156-1158
Stable URL: http://www.jstor.org/stable/1730611
Page Count: 3
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Adenosine 3′,5′-Monophosphate in Nervous Tissue: Increase Associated with Synaptic Transmission
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Abstract

Brief periods of stimulation of the preganglionic nerve fibers produced a severalfold increase in the content of adenosine 3′,5′-monophosphate in superior cervical sympathetic ganglia, whereas postganglionic stimulation did not. These and other experiments indicated that the increased concentrations of adenosine 3′5′-monophosphate were closely associated with the process of synaptic transmission. This increase occurred primarily in postsynaptic cells.

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