Access

You are not currently logged in.

Access your personal account or get JSTOR access through your library or other institution:

login

Log in to your personal account or through your institution.

Genetic Variation of Cholesterol Ester Content in Mouse Adrenals

Charles H. Doering, Seymour Kessler and R. B. Clayton
Science
New Series, Vol. 170, No. 3963 (Dec. 11, 1970), pp. 1220-1222
Stable URL: http://www.jstor.org/stable/1730659
Page Count: 3
  • More info
  • Cite this Item
Genetic Variation of Cholesterol Ester Content in Mouse Adrenals
Preview not available

Abstract

Total cholesterol concentrations in muscle, liver, and plasma do not differ significantly between adult male C57BL/10J and DBA/2J mice. In the adrenal glands of these two strains, of their hybrids, and of AC mice, concentrations of free cholesterol vary by 5 percent. Adrenals from C57 mice, however, contain six times as much esterified cholesterol as adrenals from AC or DBA mice. The intermediate concentrations of cholesterol esters in F$_{1}$ hybrids suggest that the difference in this measure is inherited additively. The finding of variation in adrenal cholesterol within a species is useful for the further study of the role of cholesterol in steroidogenesis by means of genetic analysis.

Page Thumbnails

  • Thumbnail: Page 
1220
    1220
  • Thumbnail: Page 
1221
    1221
  • Thumbnail: Page 
1222
    1222