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Cyclic Adenosine and Guanosine Monophosphates and Glucagon: Effect on Liver Membrane Potentials

Naomi Friedmann, Avril V. Somlyo and Andrew P. Somlyo
Science
New Series, Vol. 171, No. 3969 (Jan. 29, 1971), pp. 400-402
Stable URL: http://www.jstor.org/stable/1731146
Page Count: 3
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Cyclic Adenosine and Guanosine Monophosphates and Glucagon: Effect on Liver Membrane Potentials
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Abstract

Cyclic adenosine monophosphate, cyclic guanosine monophosphate, glucagon, and isoproterenol each hyperpolarized perfused rat liver cells. The hyperpolarization followed a time course similar to the stimulated increase in potassium efflux and was preceded by the increase in calcium efflux. The hyperpolarization induced by cyclic adenosine monophosphate was blocked by tetracaine. The similarity of the action of the cyclic nucleotides to that of glucagon supports the hypothesis that cyclic adenosine monophosphate is the secondary messenger mediating the action of glucagon.

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