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Neuronal GM$_{1}$ Gangliosidosis in a Siamese Cat with β-Galactosidase Deficiency

Henry J. Baker, Jr., J. Russell Lindsey, Guy M. McKhann and Donald F. Farrell
Science
New Series, Vol. 174, No. 4011 (Nov. 19, 1971), pp. 838-839
Stable URL: http://www.jstor.org/stable/1733419
Page Count: 2
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Abstract

A juvenile Siamese cat with severe, progressive motor disability was shown to have extensive neuronal degeneration caused by accumulation of GM$_{1}$ ganglioside. Tissues from brain and kidney were markedly deficient in β-galactosidase activity. The disease in this cat is thought to be inherited as an autosomal recessive trait, and is strikingly similar to juvenile GM$_{1}$ gangliosidoisis of children.

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