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Genetic Determination of Phenotypic Variation in Sickle Cell Trait

Walter E. Nance and John Grove
Science
New Series, Vol. 177, No. 4050 (Aug. 25, 1972), pp. 716-718
Stable URL: http://www.jstor.org/stable/1734769
Page Count: 3
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Genetic Determination of Phenotypic Variation in Sickle Cell Trait
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Abstract

Two genetic sources of variation influence the percentage of sickle cell hemoglobin found in heterozygotes. One factor is strongly related to the percentage of hemoglobin S in the carrier parent and appears to be determined by sickle hemoglobin isoalleles, whereas the other is related to racial background and may well be polygenic.

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