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Vasopressin: Possible Role of Microtubules and Microfilaments in Its Action

Ann Taylor, Mortimer Mamelak, Eve Reaven and Roy Maffly
Science
New Series, Vol. 181, No. 4097 (Jul. 27, 1973), pp. 347-350
Stable URL: http://www.jstor.org/stable/1736620
Page Count: 4
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Vasopressin: Possible Role of Microtubules and Microfilaments in Its Action
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Abstract

Colchicine, vinblastine, podophyllotoxin, and cytochalasin B inhibit the action of vasopressin and cyclic adenosine monophosphate on osmotic water movement across the toad bladder. The findings suggest that microtubules, and possibly microfilaments, play a role in the action of vasopressin, perhaps through involvement in the mechanism of release of secretory material from the bladder epithelial cells.

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