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Journal Article

In vivo Inhibition of Growth of Two Hormone-Dependent Mammary Tumors by Dibutyryl Cyclic AMP

Yoon Sang Cho-Chung and Pietro M. Gullino
Science
New Series, Vol. 183, No. 4120 (Jan. 11, 1974), pp. 87-88
Stable URL: http://www.jstor.org/stable/1737258
Page Count: 2
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Abstract

Growth of hormone-dependent rat mammary tumors was arrested in vivo by N$^{6}$, O$^{2^{\prime}}$-dibutyryl cyclic adenosine 3′, 5′-monophosphate. Estrogen concentration did not change, but acid ribonuclease activity and synthesis increased during treatment with the dibutyryl cyclic nucleotide, as was shown during tumor regression due to hormonal deprivation. Growth arrest, thus, appears to derive from enhanced tissue catabolism.

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