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Aging Increases Susceptibility of Mouse Skin to DMBA Carcinogenesis Independent of General Immune Status

P. Ebbesen
Science
New Series, Vol. 183, No. 4121 (Jan. 18, 1974), pp. 217-218
Stable URL: http://www.jstor.org/stable/1737375
Page Count: 2
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Abstract

The dependence of chemical carcinogenesis on age of target tissue was studied by repeated DMBA-treatment of mouse skin grafted from old and young syngeneic donors to young recipients. Carcinomas developed on 39 percent (16/41) of grafts from old donors and on 12 percent (5/41) of grafts from young donors. The incidence of nonskin lymphoid tumors was highest in male recipients bearing grafts from old donors.

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