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Adenosine 3′,5′-Monophosphate: Inhibition of Complement-Mediated Cell Lysis

Michael Kaliner and K. Frank Austen
Science
New Series, Vol. 183, No. 4125 (Feb. 15, 1974), pp. 659-661
Stable URL: http://www.jstor.org/stable/1737708
Page Count: 3
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Adenosine 3′,5′-Monophosphate: Inhibition of Complement-Mediated Cell Lysis
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Abstract

An increase in adenosine 3′,5′-monophosphate (cyclic AMP) in rat mast cells, achieved by stimulating the cells with prostaglandin E$_{1}$, by preventing cyclic AMP breakdown with aminophylline, or by adding exogenous dibutyryl cyclic AMP, prevented complement-mediated cytolysis as assessed by both histamine release and vital dye exclusion. Dibutyryl cyclic AMP also suppressed water-induced osmotic lysis.

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