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Lysergic Acid Diethylamide: Effect on Histone Acetylation in Rabbit Brain

Ian R. Brown and C. C. Liew
Science
New Series, Vol. 188, No. 4193 (Jun. 13, 1975), pp. 1122-1123
Stable URL: http://www.jstor.org/stable/1740109
Page Count: 2
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Abstract

Lysergic acid diethylamide increased acetylation of histones in rabbit cerebral hemispheres and midbrain 30 minutes after intravenous administration of the drug at doses of 10 and 100 micrograms per kilogram of body weight. Evidence for the stimulation of acetylation in individual histone bands was obtained after separation by electrophoresis on polyacrylamide gels.

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