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Journal Article

Nuclear Protein Matrix: Association with Newly Synthesized DNA

Ronald Berezney and Donald S. Coffey
Science
New Series, Vol. 189, No. 4199 (Jul. 25, 1975), pp. 291-293
Stable URL: http://www.jstor.org/stable/1740144
Page Count: 3

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Topics: DNA, Liver, Nuclear proteins, Steam, Nuclear structure, Oceans, Hepatectomy, Centrifugation, Pumps, Solar energy
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Nuclear Protein Matrix: Association with Newly Synthesized DNA
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Abstract

The residual structural framework of the cell nucleus, termed the nuclear protein matrix, is associated with newly synthesized DNA in regenerating rat liver. One minute after rats are injected with [$^{3}$H]thymidine, more than 90 percent of the total tritium in nuclear DNA is associated with the matrix DNA although this DNA comprises only 25 percent of the total nuclear DNA. In contrast, the bulk DNA, 75 percent of total nuclear DNA, contains less than 8 percent of the total labeled DNA. The percentage of total labeled DNA associated with the bulk DNA increases for 30 minutes after injection and decreases correspondingly in the matrix DNA.

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